Buspirone

Anxiolytic agent.The drug does not act on benzodiazepine receptors.It enhances the activity of specific noradrenergic& dopaminergic pathways & reduces activity of serotonin & acetylcholine.

Indications

Short term management of anxiety disorders and the relief of symptoms of anxiety with or without accompanying depression.

Dosage

Initial 5 mg 2-3 times daily, dose may be increased every 2-3 days. Maint 15 mg-30 mg daily. Max 45 mg daily.

Contra-Indications

Hypersensitivity, epilepsy, severe renal & hepatic disease, pregnancy & lactation.

Special Precautions

History of renal or hepatic impairment, alcoholics.

Side Effects

Dizziness, headache, nervousness, light headedness, excitment and nausea. Rarely tachycardia, palpitations, chest pain, drowsiness, confusion, dry mouth, fatigue, sweating.

Drug Interactions

Elevation of blood pressure in combination with MAO inhibitors. Elevates blood Digoxine levels. Avoid alcohol. Caution with other CNS active agents. Elevated BP if used with MAOI. Increases serum haloperidol. May increase digoxin toxicity.