Clindamycin
Clindamycin is a semi-synthetic lincosamide antibiotic commonly used to treat bacterial infections. It works by inhibiting protein synthesis in susceptible bacteria, thereby preventing their growth. Clindamycin can be administered orally, topically, or intravenously, depending on the specific indication and severity of the infection.Respiratory tract, (Staphylococci and Pneumococci) Skin and Soft tissue, Dental, nasopharyngeal infections.
Mild to moderately severe infection 150 to 300 mg 6 hourly. Severe infections : 300 to 450 mg 6 hourly.
Hypersensitivity to clindamycin or Lincomycin. newborns and infants. Meningitis. Antagonism between clindamycin and Erythromycin.
Use in Atopic individuals, Periodic liver function test and blood count, Hepatic and renal impairment. Paediatrics: Contraindicated in infants. Pregnancy: Contraindicated. Lactation: Contraindicated. Elderly: Increased risk of side effects.
Urticaria, rashes, abdominal pain, nausea, vomiting, diarrhoea, Jaundice and Liver abnormalities, eosinophilia.
Erythromycin act as an antagonist, pancuronium induced neuromuscular blockade, reduced absorption rate in presence of kaolin-pectin, synergistic effect with gentamycin.
