FLUCONAZOLE with TINIDAZOLE

Fluconazole and Tinidazole are medications used to treat various fungal and protozoal infections. Fluconazole belongs to the class of antifungal drugs, while Tinidazole is an antiprotozoal agent. Together, they provide a comprehensive approach to treating certain infections. Oesophageal candidiasis, Oropharyngeal candidiasis, Vaginal candidiasis, Systemic candidiasis, Cryptococcal meningitis, Coccidioidomycosis, Histoplasmosis, Prophylaxis in bone marrow transplantation, Candidiasis in immunocompromised individuals, Peritonitis.

Indications

-Fungal Infections: Fluconazole is effective against a range of fungal infections, including candidiasis, cryptococcal meningitis, and others. -Protozoal Infections: Tinidazole is primarily used for the treatment of protozoal infections like giardiasis and trichomoniasis.

Dosage

-Dosage may vary depending on the specific infection and individual patient factors. It is crucial to follow the prescribed regimen provided by the healthcare professional. Typically, doses are administered orally. -Adult: 200 - 400 mg once daily -Systemic candidiasis: Maximum dose: 400 mg .The drug should be administered 2 more weeks after resolution of symptoms. -Oropharyngeal candidiasis: Initial dose: 200 mg once daily followed by 100 mg once daily. The drug should be administered at least 14 days after resolution of symptoms.

Contra-Indications

-Hypersensitivity: Patients with a known hypersensitivity to either fluconazole or tinidazole. -Pregnancy and Breastfeeding: Consultation with a healthcare provider is essential during pregnancy and breastfeeding.

Special Precautions

-Liver Dysfunction: Caution is advised in patients with liver impairment. -Neurological Disorders: Patients with a history of neurological disorders may need careful monitoring. Before using Fluconazole with Tinidazole, inform your doctor about your current list of medications, over the counter products, allergies, pre-existing diseases, and current health conditions. Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert.

Side Effects

Common side effects may include nausea, headache, dizziness, and gastrointestinal disturbances. Serious side effects are rare but may include allergic reactions, liver problems, or neurological symptoms. Abdominal pain, Nausea, Vomiting, Diarrhoea, Alopecia, Headache, Rash, Alteration in liver enzyme

Drug Interactions

Fluconazole / Tinidazole may interact with the following drugs and products: Acetaminophen Alcohol Alfentanil Aliskiren Alprazolam Amitriptyline Amlodipine Artesunate Ascorbic acid Astemizole