ILAPRAZOLE

Ilaprazole is a proton pump inhibitor (PPI) used to reduce stomach acid production. It is effective in treating conditions related to excessive stomach acid, such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome. By inhibiting the proton pump in the stomach lining, Ilaprazole decreases the amount of acid produced, providing relief from acid-related symptoms and allowing healing of the digestive tract.

Indications

-Gastroesophageal reflux disease (GERD) -Peptic ulcer disease -Zollinger-Ellison syndrome -Erosive esophagitis -Helicobacter pylori eradication (as part of combination therapy)

Dosage

-The usual dose of Ilaprazole is 10 mg to 20 mg once daily, taken before a meal. -For GERD and erosive esophagitis, treatment duration typically ranges from 4 to 8 weeks. -In cases of peptic ulcers, treatment may extend to 6 to 8 weeks. -Dosage adjustments may be necessary based on individual response and specific conditions.

Contra-Indications

-Hypersensitivity to Ilaprazole or any of its components -Severe liver impairment -Pregnancy and lactation (unless deemed necessary by a healthcare provider)

Special Precautions

-Use with caution in patients with moderate liver impairment. -Long-term use may increase the risk of fractures, hypomagnesemia, and vitamin B12 deficiency. -Monitor patients for signs of Clostridium difficile-associated diarrhea. -Avoid concomitant use with medications that require an acidic environment for absorption.

Side Effects

-Common: headache, nausea, diarrhea, abdominal pain, constipation -Rare: dizziness, rash, pruritus, elevated liver enzymes -Very rare: severe allergic reactions, Stevens-Johnson syndrome, interstitial nephritis

Drug Interactions

-May interact with drugs such as warfarin, diazepam, phenytoin, and other PPIs. -Can reduce the absorption of drugs that require an acidic environment (e.g., ketoconazole, itraconazole). -Potential interaction with clopidogrel, reducing its antiplatelet effect.