LAMIVUDINE

Lamivudine is a synthetic nucleoside analogue with activity against the human immunodeficiency virus (HIV). It belongs to the class of anti-HIV agents called the nucleoside reverse transcriptase inhibitors. Lamivudine is the (-) enantiomer of a dideoxy analogue of cytidine.

Indications

Treatment of HIV infection in combination with Zidovudine.

Dosage

Adults: 150 mg twice daily in combination with zidovudine. For adults with low body weight (less than 50 Kg or 110 lb): recommended oral dose is 2 mg/Kg twice daily. Paediatric Patients (3 months to 12 years): 4 mg/Kg twice daily in combination with zidovudine.

Contra-Indications

Hypersensitivity, Patients with impaired renal function.

Special Precautions

Pregnancy: Use only, if the potential benefits outweigh the potential risk. Lactation: Not recommended.

Side Effects

Headache, malaise, fatigue, nausea, anorexia, abdominal cramps, neuropathy, insomnia, sleep related disorders, dizziness, depressive disorders, nasal sign and symptoms, cough and skin rashes.

Drug Interactions

Trimethoprim 160 mg and sulfamethoxazole 800 mg once daily has been shown to increase lamivudine exposure.