Rabies immunoglobulin

Rabies Immunoglobulin is a specialized medication used as part of post-exposure prophylaxis (PEP) in individuals who have been exposed to the rabies virus. It contains antibodies that provide immediate passive immunity until the body can produce its own antibodies in response to the rabies vaccine.

Indications

-Rabies Exposure: Administered to individuals who have been exposed to potentially rabid animals or have sustained bites or scratches from such animals. -Post-Exposure Prophylaxis (PEP): Used alongside the rabies vaccine to prevent the onset of rabies.

Dosage

-Standard Dosage: The dosage is typically 20 IU/kg of body weight, administered intramuscularly at the site of the wound or, if not feasible, in the gluteal area. -Timing: Ideally administered as soon as possible after exposure. It should be given in conjunction with the rabies vaccine according to the recommended PEP schedule.

Contra-Indications

-Allergy: Hypersensitivity to any component of the immunoglobulin. -Pregnancy: Use during pregnancy should be considered only if the benefit outweighs the risk, and consultation with a healthcare provider is necessary.

Special Precautions

-Pre-existing Conditions: Use cautiously in individuals with immunodeficiency conditions or those receiving immunosuppressive therapy. -Pregnancy and Lactation: Use with caution and under medical supervision in pregnant or lactating women.

Side Effects

Local tenderness, muscle soreness or stiffness at the injection site, low grade fever, sensitisation to repeated injection of human globulin in immunoglobulin -deficient patients.

Drug Interactions

Vaccines: May interfere with the efficacy of live vaccines. It is generally recommended to administer live vaccines either simultaneously with immunoglobulin or at least 3 months after administration.