Zolpidem
It is a non-benzodiazepine sedative drug belonging to the imidazopyridine class. It preferentially binds to omega-1 receptors. The selective binding may explain the relative absence of myelorelaxant and anti-convulsant effects of zolpidem.Short term treatment of insomnia.
Adult : 10mg before bedtime. Dosage may be altered when patients are on drugs known to have central nervous system depressant effect. Elderly/deblitated patients: Initial 5mg. Max: 10mg daily.
Hypersensitivity to zollidem. Obstructive sleep apnea, Myasthenia gravis, Severe heaptic insufficiency, Acute pulmonary insufficiency and Respiratory depression.
Neonates, children, nursing mothers, pregnancy. Normal dosage to be altered in patients with hepatic insufficiency. Caution in patients exhiniting symptoms of depression. Patients should be warned from doing any jobs involving mental alertness or motor coordination after ingestion the drug.
Amnesia, drowsiness, back pain, chest pain, headache, malaise, pulmonary embolism, confusion, urinary tract infection, dry mouth, diplopia.
Zolpidem with alcohol presents with enhanced sedative action. Others: Rifampicin, singnificantly reduces the plasma concentration and effects of zolpidem.
