Doxifluridine

Doxifluridine is an antineoplastic agent used in the treatment of various types of cancer. It is a fluoropyrimidine analogue that functions as a prodrug, converting into 5-fluorouracil in the body.

Indications

-Colorectal cancer -Gastric cancer -Pancreatic cancer

Dosage

-Adults: Typically, 1,000 mg/m² administered intravenously every 3 weeks. Dosage may vary based on the type of cancer and patient condition. -Pediatric: Dosage not well-established. Use with caution and based on clinical judgment.

Contra-Indications

-Hypersensitivity to Doxifluridine or 5-fluorouracil -Severe hepatic impairment -Pregnancy (Category D) and lactation

Special Precautions

-Monitor liver function regularly. -Caution in patients with renal impairment. -Use in conjunction with appropriate antiemetic therapy. -Monitor for signs of gastrointestinal toxicity.

Side Effects

-Nausea and vomiting -Diarrhea -Mucositis -Bone marrow suppression (anemia, leukopenia, thrombocytopenia) -Hand-foot syndrome -Hepatotoxicity

Drug Interactions

-With Anticoagulants: Increased risk of bleeding. -With Phenytoin: Potential for altered phenytoin levels. -With Other Antineoplastics: Increased risk of additive toxicities.