PROCYCLIDINE-HCL

Procyclidine-HCL is an anticholinergic medication used primarily to treat symptoms of Parkinson's disease and extrapyramidal symptoms caused by antipsychotic drugs. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Indications

Parkinsonism, drug induced extra-pyramidal symptoms, spasticity, closed cranio-cerebral trauma with concussion syndrome. Trigeminal neuralgia. Nicotine poisoning. Adjunct in Parkinsonism therapy.

Dosage

Initially 2.5 mg thrice daily after meals increasing at intervals of 2-3 days by 2.5-5 mg daily. Usual max. : 30 mg daily. Not recommended for children.

Contra-Indications

Acute narrow angle glaucoma, urinary retention, tachycardia, paralytic ileus, prostatic hypertrophy.

Special Precautions

-Tendency to convulsion. recent M.I. concurrent admin. of C.N.S. depressants. -Paediatrics: Not recommended. -Pregnancy: Safety not clearly established. Lactation: Safety not clearly established. Elderly: Strict supervision and dosage monitoring.

Side Effects

Dryness of mouth, blurring of vision, headache, nausea, nervousness. Impairment of memory and organic confusional states, dizziness, constipation, delusions and hallucinations.

Drug Interactions

Tricyclic antidepressants, antiparkinsonism drugs, anti-histaminics, phenothiazines and quinidines have anticholinergic. Other oral drugs delays absorption.