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PROCYCLIDINE-HCL

PROCYCLIDINE-HCL

These drugs have a higher central peripheral anticholinergic action than atropine but pharmacological profile is similar to it. They acts by reducing imbalanced cholinergic activity in striatum of parkinsonian patients. Tremor is benefited more than rigidity; hypokinesia is affected the least. Sialorrhoea is controlled by their peripheral action. The overall efficacy is much lower than levodopa. However, they are cheap and produce less side effects than levodopa. They can be combined with levadopa in an attempt to lower its dose.

Indications

Parkinsonism, drug induced extra-pyramidal symptoms, spasticity, closed cranio-cerebral trauma with concussion syndrome. Trigeminal neuralgia. Nicotine poisoning. Adjunct in Parkinsonism therapy.


Dosage

Initially 2.5 mg thrice daily after meals increasing at intervals of 2-3 days by 2.5-5 mg daily. Usual max. : 30 mg daily. Not recommended for children.


Contra-Indications

Acute narrow angle glaucoma, urinary retention, tachycardia, paralytic ileus, prostatic hypertrophy.


Special Precautions

Tendency to convulsion. recent M.I. concurrent admin. of C.N.S. depressants. Paediatrics: Not recommended. Pregnancy: Safety not clearly established. Lactation: Safety not clearly established. Elderly: Strict supervision and dosage monitoring.


Side Effects

Dryness of mouth, blurring of vision, headache, nausea, nervousness. Impairment of memory and organic confusional states, dizziness, constipation, delusions and hallucinations.


Drug Interactions

Tricyclic antidepressants, antiparkinsonism drugs, anti-histaminics, phenothiazines and quinidines have anticholinergic. Other oral drugs delays absorption.


Other Brands With Same Generic
Brand Name Manufactured by
PROLY Axis Life Science Pvt.Ltd.
RELIDRIN RELIANCE LIFECARE PVT LTD
Other Combination Brands
Brand Name Manufactured by
ABROS HAIR SERUM ABROS (DIVISION OF LUMAIRE LABS PVT. LTD.)
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