Temsirolimus

It is an inhibitor of mTOR, is an antineoplastic agent.

Dosage

IV; 25mg once a week, dosage adjusted

Contra-Indications

Hypersensitivity, liver impairement

Special Precautions

infusion reaction, hepatic impairement Paediatric: Safety and efficacy in children not yet established Pregnancy: Category D Lactation: excreted in milk Elderly: Caution to be exercised

Side Effects

Skin rash, Weakness or fatigue, Mouth sores, Nausea, Swelling or fluid retention, Loss of appetite

Drug Interactions

inhibitor or inducer of CYP3A, CYP2D6