Abiraterone Acetate

Abiraterone Acetate is a medication used to treat prostate cancer. It works by inhibiting the production of androgens (male hormones) that fuel the growth of prostate cancer cells.

Indications

-Prostate Cancer: Primarily used for metastatic castration-resistant prostate cancer (mCRPC) in combination with prednisone or prednisolone. -Advanced Prostate Cancer: For patients who have not responded to other treatments.

Dosage

-Standard Dosage: 1,000 mg taken orally once daily, in combination with 5 mg of prednisone taken twice daily. -Administration: Should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.

Contra-Indications

-Pregnancy: Not recommended for use in pregnant women due to potential harm to the fetus. -Severe Hepatic Impairment: Use with caution or avoid in patients with severe liver impairment.

Special Precautions

-Liver Function: Regular monitoring of liver function tests is required. -Adrenal Insufficiency: May cause adrenal insufficiency; monitor for symptoms and consider corticosteroid supplementation if needed. -Hypertension: Monitor blood pressure regularly; manage hypertension as necessary.

Side Effects

-Common: Fatigue, joint pain, hot flushes, diarrhea, nausea, and high blood pressure. -Serious: Liver problems, heart issues, adrenal insufficiency, and allergic reactions.