Agomelatine Agotine

Agomelatine is a new antidepressant that is a potent agonist of melatonin receptors and an antagonist of the serotonin 5-HT2C receptor subtype. It is used for major depressive disorder , with overall mild to moderate side effects. Agomelatine is an atypical antidepressant that works as an agonist of melatonin receptors and an antagonist of serotonin receptors.

Indications

- Agomelatine is primarily indicated for the treatment of major depressive disorder (MDD) in adults. - Major depressive disorder

Dosage

-The usual dosage is 25 mg taken orally once daily at bedtime. The dosage may be adjusted based on the individual's response to treatment. -oral’ 25-50 mg once daily

Contra-Indications

-Agomelatine is contraindicated in patients with severe hepatic impairment, as it is metabolized in the liver. -Hypersensitivity, Cirrhosis/liver failure

Special Precautions

-Caution should be exercised in patients with liver dysfunction. Regular monitoring of liver function is recommended during treatment. Liver function to be monitored during treatment Paediatric: Safety and efficacy not yet established Pregnancy: Data not sufficient in humans. In animal studies no effect on fertility, embryofetal development and pre and post natal development is seen. Lactation: Data not sufficient Elderly: No effect documented in > 75 years age, so it should not be used in this age group

Side Effects

-Common side effects include headache, dizziness, fatigue, nausea, diarrhea, and insomnia. In rare cases, there may be liver function abnormalities. -dizziness, sleepiness, insomnia, migraine, headache, diarrhoea, constipation, abdominal pain, excessive sweating, back pain, tiredness, anxiety, increased levels of liver enzymes in your blood, vomiting, paraesthesia, blurred vision, restless legs syndrome , agitation, abnormal dreams, erythematous rash, swelling, hepatitis.

Drug Interactions

-Agomelatine may interact with other drugs, particularly those that affect the liver enzymes. It is important to inform the healthcare provider of all medications being taken. -CYP1A2 inhibitors (e.g. fluvoxamine, ciprofloxacin), estrogen, rifampicin