Alendronate Sodium

It is a third generation bisphosphonate, with a high potential in the treatment of postmenopausal osteoporosis. The bisphonates does not undergo enzymatic degradation by skeletal pyrophosphatases and persists in the skeleton prolonged periods.

Indications

Teatment of postmenopausal osteoporosis.

Dosage

10mg once daily.

Contra-Indications

Hypocalcemia and hypersensitivity. Patient with esophageal abnormalities.

Special Precautions

Patient with acute upper gastrointestinal problem. Hypocalceamia, causes of oesteoporosis. Paediatrics: Should not be given. Pregnancy: Should not be given. Lactation: Should not be given. Elderly: Greater sensitivity to Alendronate.

Side Effects

Abdominal pain, nausea, dyspepsia, consipation, diarrhoea, oesophageal ulcer, faltulence, acid regurgitation, vomiting, dysphagia, abnormal distention, headache, musculoskeletal pain.

Drug Interactions

Calcium supplements and antacids may interfere with the absorption of Alendronate. Aspirin containing compounds may increase the incidences of GI side effects.