Altretamine

Altretamine (Hexalen) is a drug prescribed to treat ovarian cancer. Altretamine is an Alkylating Drug. Easy-to-read more about Altretamine medicine Includes special instructions, precautions, drug interactions and pregnancy safety information.

Indications

Ovarian cancer.

Dosage

260mg/m2/day in 4 divided doses, for 14 or 21 consecutive days out of a 28 days cycle, up to 12 cycles.

Contra-Indications

Hypersensitivity, bone marrow suppression, neurological toxicity.

Special Precautions

Paediatric: Safety not established. Pregnancy: Category D; risk to fetus. Lactation: Secreted in milk; discontinue breast feeding.

Side Effects

Bone-marrow depression eg, leukopaenia and thrombocytopaenia. Nausea and vomiting, myelosuppression, peripheral and central neuropathies; CNS symptoms, dose-limiting renal toxicity, rarely, rashes, anaemia, alopoecia, hepatic toxicity.

Drug Interactions

Pyridoxine, reduced response to vaccines, digoxin, oral anticoagulants, phenytoin, suxamethonium, amitriptyline, imipramine.