AMISULPRIDE

Amisulpride is an antipsychotic medication primarily used to treat schizophrenia and dysthymia. It works by blocking certain receptors in the brain to help stabilize mood and behavior.

Indications

-Schizophrenia -Acute psychotic episodes -Dysthymia

Dosage

-Schizophrenia: The typical dose ranges from 400 mg to 800 mg per day, divided into two doses. -Dosage may vary based on individual patient needs and response. -Dysthymia: A lower dose, typically around 50 mg to 300 mg per day, is used.

Contra-Indications

-Known hypersensitivity to Amisulpride or any of its components -Prolactin-dependent tumors (e.g., pituitary gland prolactinoma and breast cancer) -Pheochromocytoma -Severe renal impairment

Special Precautions

-Use with caution in patients with a history of epilepsy or seizures. -Monitor patients for signs of extrapyramidal symptoms (EPS) and tardive dyskinesia. -Caution in patients with diabetes or risk factors for diabetes. -Regular monitoring of liver function and blood counts is recommended.

Side Effects

-Common: Insomnia, anxiety, agitation, headache, dizziness, gastrointestinal disturbances -Serious: Extrapyramidal symptoms, hyperprolactinemia, weight gain, QT prolongation, neuroleptic malignant syndrome

Drug Interactions

-CNS depressants: May enhance the sedative effect of other CNS depressants. -Antihypertensive agents: May increase the risk of hypotension. -Drugs affecting cardiac conduction: Use with caution due to potential for QT prolongation.