AMISULPRIDE
Amisulpride is a dopamine D2 receptor antagonist used to treat acute and chronic schizophrenia in adults, as well as to prevent and treat postoperative nausea and vomiting. Amisulpride, as an antipsychotic medication, relieves both positive and negative symptoms of schizophrenia, and it has antidepressant qualities in individuals with psychiatric illnesses, dysthymia, and major depression.5 Amisulpride functions primarily in the limbic system, which explains its lower likelihood of extrapyramidal side effects when compared to other atypical antipsychotic medications. Amisulpride oral pills are used to treat acute and chronic schizophrenia, as well as secondary negative symptoms in mental health problems such as affective disorders, depressive mood, and mental retardation. Amisulpride is used both as an oral and intravenous formulation to treat and prevent postoperative nausea and vomiting in adults, either alone or in combination with other antiemetic medicines.Adults should receive intravenous amisulpride to prevent postoperative nausea and vomiting, either alone or in combination with a different type of antiemetic. It is also approved for the treatment of postoperative nausea and vomiting in patients who have previously received anti-emetic prophylaxis with a different class of drug or have not received prophylaxis. Oral amisulpride is used to treat acute and chronic schizophrenic disorders characterised by positive symptoms such as delusions, hallucinations, thought disorders, hostility, and suspicious behaviour, or primarily negative symptoms such as blunted affect, emotional and social withdrawal (deficit syndrome). Amisulpride also regulates secondary negative symptoms in productive situations and affective disorders such as depression or retardation.
The recommended dosage of amisulpride is 400 to 800 mg per day, but quantities less than or equal to 1200 mg per day may also be used.
The use of amisulpride is prohibited in the following disease conditions and populations: Pheochromocytoma, is a small vascular tumour of the adrenal medulla that causes erratic adrenalin and noradrenaline secretion, resulting in bouts of high blood pressure, palpitations and headache. Concurrent prolactin-dependent malignancies, such as prolactinoma and breast cancer Disorders of movement (for example, Parkinson's disease and dementia with Lewy bodies) Lactation Before the onset of puberty, children It is also not advised to use amisulpride in patients who are hypersensitive to amisulpride or the excipients included in its dose form.
Should not be taken in along with levodopa as if taken together they can have substantial side effects. Amisulpride can cause abnormalities in cardiac rhythms, including QT prolongation and cause fainting or serious side effects in some patients by altering the way their hearts beat. Some people may experience fast, pounding, or uneven heartbeats
Common side effects Extrapyramidal symptoms (EPS), including parkinsonism dystonia, tremor and akathisia, Insomnia, Somnolence, Hypersalivation, Nausea, Headache, Hyperactivity, Vomiting, Hyperprolactinaemia, Weight gain, Constipation, Parched mouth, Accommodation disorder, Vision blur, Rare Side effects : Hyponatraemia, Bradycardia, Hypotension, Palpitations, Urticaria, Seizures, Mania, Ocularlogyric crisis, Tardive dyskinesia, Agranulocytosis, neutropenia, and leucopenia
