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Ampicillin with Probenecid

Ampicillin with Probenecid

-Ampicillin belongs to the penicillin class of antibiotics. Probenecid is a potent uricosuric agent. It is used to treat severe bacterial infections. -Ampicillin with Probenecid is a combination medication that includes ampicillin, a broad-spectrum antibiotic, and probenecid, a drug that enhances the effectiveness of ampicillin by slowing its elimination from the body. Here's detailed information about Ampicillin with Probenecid.: -Ampicillin is a penicillin-type antibiotic that works by interfering with the formation of the bacterial cell wall, leading to the death of susceptible bacteria. Probenecid, on the other hand, increases the concentration of ampicillin in the blood by inhibiting its renal excretion, thereby enhancing its therapeutic effect.


-This combination is primarily prescribed for the treatment of various bacterial infections caused by susceptible strains, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain sexually transmitted diseases. -Bacterial infections like urinary tract infections, gout, and skin problems.


-The dosage of Ampicillin with Probenecid will vary depending on the specific infection being treated. It is crucial to follow the prescribed dosage and administration instructions provided by the healthcare professional.


-This medication is contraindicated in individuals with a known hypersensitivity to penicillins or probenecid. Patients with a history of severe allergic reactions to these drugs should avoid its use. -Cardiac diseases, renal impairment, liver diseases and gastritis.

Special Precautions

-Inform your healthcare provider about any history of allergies or kidney problems. -Exercise caution in patients with a history of gastrointestinal disease. -Regular monitoring of kidney function is advisable during treatment. -It is not recommended to consult a physician before taking ampicillin and probenecid combination during pregnancy and breastfeeding.

Side Effects

-Common side effects may include nausea, vomiting, diarrhea, rash, and allergic reactions. Serious side effects such as severe skin reactions or blood disorders are rare but require immediate medical attention. -Allergic reaction, mouth ulcer, headache, dizziness, weakness, diarrhoea, indigestion, vomiting, obesity, cough and breathlessness.

Drug Interactions

-Probenecid may interact with other drugs that are eliminated through the kidneys, potentially leading to increased blood levels of those drugs. -Concurrent use with other antibiotics or medications should be carefully monitored. -Methotrexate, aspirin, warfarin, atenolol, tetracycline, chloramphenicol.

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