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Ampicillin with Sulbactam sodium

Ampicillin with Sulbactam sodium

Sulbactam sodium is irreversible betalactamase inhibitor thus it increases the activity of ampicillin against beta lactamase producing organisms. Spectrum of activity of this combination of ampicillin with sulbactam sodium includes beta lactamase and non-beta lactamase producing strains of gram-positive Bacteria staphylococcus aureus, staphylococcus epidermidis staphylococcus saprophyticus and other strains Streptococcus faecalis, streptococcus pneumoniae, streptococcus pyogenes, Streptococcus viridans.Gram-negative bacteria: Beta-lactamase and non beta-lactamase producing strains of Hemophilus influenzae, Branhamella Catarrhalis, Escherichia Coli, Neisseria gonorrhoea, Proteus mirabilis and other strains of Klebsiella species, Proteus Vulgaris, Providencia rettgeri, Providencia stuartii, Marganella morganii. Anaerobes: Clostridium species, Peptococcus species, Peptostreptococcus species, Bacteroides species including B fragilis


Pre, intra and post operative use for the prevention and treatment of surgical infections, Surgical prophylaxis, Intra-abdominal infections, Post-surgical infections, suture infections, Obstetrics and gynaecological infections, Bone and joint infections, Respiratory tract infections, Gonorrhoea, Skin & soft tissue infections, Infections in immunocompromised patients


I.V. slow injection over or atleast 10-15 mins, or in greater dilutions with 50-100 ml of a compatible diluent as an intravenous infusion over 15-30 mins. It can also be administered by deep intra muscular injection. 1.5 gm [0.5 gm Sulbactam (as sod), 1 gm Ampicillin (as sod) to 3 gm (1 gm Sulbactam (as sod), 2 gm Ampicillin (as sod)] every 6 hrs. Max 4 gm per day.



Special Precautions

Pregnancy, Nursing mother, not in infants and children under age of 12 , concurrent use with allopurinol.

Side Effects

Diarrhoea, rash, Gastritis, stomatitis, black hairy tongue, enterocolitis, pseudomembranous colitis, nausea, vomiting, urticaria, erythema multiforme, agranulocytosis.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. Keep a list of all the products you use and share it with your doctor and pharmacist.

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