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It is monobactam antibiotic useful to treat sepsis and other gram negative infections. It is found to be active against a wide range of gram negative aerobic bacteria especially against Pseudomonas aeruginosa.


Septicemia/Bacteremia, Pyelonephritis and complicated urinary tract infection, Gram-negative lower respiratory tract infection, Gonorrhoea. Aztreonam is also used in other gram negative infections like: Skin and soft tissue infection, Intra-abdominal infection, Gynecologic infections, Adjunct to surgery in the treatment of abscesses, cutaneous and serous surface infections and infections in hollow viscous perforations.


The dosage for severe or life threatening infection is 2 g every 6 to 8 hours IV or IM. In urinary tract infection 0.5-1g 8 or 12 hourly, and in moderately severe infection 1 or 2 g 8 or 12 hourly is recommended. The total daily dose should not exceed 8g.


Hypersensitivity, Pregnancy.

Special Precautions

Prescribing Aztreonam in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Side Effects

Reaction at the site of injection, urticaria.

Drug Interactions

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

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