Bezafibrate

It suppresses endogenous cholesterol synthesis, causing the expression of an increased number of specific LDL (low density lipoproteins) receptors and thus an increased catabolism of LDL which leads to lower plasma cholesterol. It also suppresses the endogenous synthesis of triglycerides while simultaneousy stimulating their catabolism through systemic lipoprotein lipase and hepatic lipase.

Indications

Type IIa, IIb, III, IV & V hyperlipidaemias resistant to diet alone.

Dosage

200 mg three times daily with food.

Contra-Indications

Gall bladder disease. Pregnancy, lactation, kidney or liver dysfunction, Nep-hrotic syndrome.

Special Precautions

Discuss with your doctor if you have liver disease, pre-existing kidney disease, heart disease, any allergies. Bezafibrate is not recommended for use during pregnancy or breast-feeding. Discuss the risks and benefits with doctor.

Side Effects

Myalgia, diarrhoea, skin rashes. Reversible alopecia, decreased libido. G.I. upset.

Drug Interactions

Action of sulphonylureas potentiated.