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It is a competitive antagonist of the beta-adrenergic receptors. It has high beta1 selectivity. There is no membrane-stabilising or partial agonist action. Reduction in heart rate and blood pressure. Action lasts for 24 hrs.


Hypertension,Coronary artery disease.


Start at 2.5 or 5mg/day and build up to10 -20mg/day.Dose reduction in severe renal impairment.


Bradycardia, second or third degree heart block, conduction abnormalities, congestive heart failure, chronic obstructive pulmonary disease, peripheral vascular insufficiency, pregnancy and lactation.

Special Precautions

Poor L.V function, bronchial asthma, diabetes, thyrotoxicosis, M.I, severe renal impairment, abrupt withdrawal. Paediatrics: Not recommended. Pregnancy: Safety not established. Lactation: Use with caution. Elderly: Use with caution.

Side Effects

Giddiness, headache, fatigue, brady-cardia, nausea, dyspnoea, sleepdisturbances, cold extremities, reduced libido.

Drug Interactions

Enhances the action of anaesthetic agents, clonidine, calcium antagonists, hypoglycaemic agents & NSAIDs. Rifampicin cause reduction in plasma concentration & elimination half-life of drug.

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