Bisoprolol
It is a competitive antagonist of the beta-adrenergic receptors. It has high beta1 selectivity. There is no membrane-stabilising or partial agonist action. Reduction in heart rate and blood pressure. Action lasts for 24 hrs. It works by blocking the effects of certain natural substances such as adrenaline on the heart and blood vessels.Hypertension, Coronary artery disease. Chronic heart failure Prevention of future cardiovascular events in patients with a history of myocardial infarction (heart attack)
Start at 2.5 or 5mg/day and build up to10 -20mg/day.Dose reduction in severe renal impairment.
Bradycardia, second or third degree heart block, conduction abnormalities, congestive heart failure, chronic obstructive pulmonary disease, peripheral vascular insufficiency, pregnancy and lactation.
Poor L.V function, bronchial asthma, diabetes, thyrotoxicosis, M.I, severe renal impairment, abrupt withdrawal. Paediatrics: Not recommended. Pregnancy: Safety not established. Lactation: Use with caution. Elderly: Use with caution.Abrupt discontinuation of bisoprolol should be avoided, especially in patients with coronary artery disease, as it may lead to exacerbation of symptoms. Bisoprolol should be used cautiously in patients with certain respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD).
Giddiness, headache, fatigue, brady-cardia, nausea, dyspnoea, sleepdisturbances, cold extremities, reduced libido.
Enhances the action of anaesthetic agents, clonidine, calcium antagonists, hypoglycaemic agents & NSAIDs. Rifampicin cause reduction in plasma concentration & elimination half-life of drug.
