Brivaracetam

Brivaracetam is an antiepileptic medication belonging to the racetam class. It is chemically related to levetiracetam and is used in the management of epilepsy. Brivaracetam is believed to exert its antiepileptic effects by modulating synaptic vesicle protein 2A (SV2A) in the brain.

Indications

-Brivaracetam is indicated for the treatment of partial-onset seizures in adults and adolescents aged 16 years and older with epilepsy. -partial-onset seizures in patients 1 month of age and older.

Dosage

-Brivaracetam is indicated for the treatment of partial-onset seizures in adults and adolescents aged 16 years and older with epilepsy. -partial-onset seizures in patients 1 month of age and older.

Contra-Indications

-Brivaracetam is contraindicated in patients with a known hypersensitivity to the drug or its components. -Hypersensitivity

Special Precautions

-Caution should be exercised in patients with a history of psychiatric disorders, as brivaracetam has been associated with psychiatric adverse reactions. -Patients should be monitored for signs of hypersensitivity reactions, and the drug should be discontinued if such reactions occur. -Abrupt withdrawal of brivaracetam may lead to increased seizure frequency; therefore, the dosage should be tapered gradually if discontinuation is necessary. -Paediatric: Safety and effectiveness of BRIVARACETAM have been established in pediatric patients 1 month to less than 16 years of age. Pregnancy: Data not sufficient Lactation: Data not sufficient Elderly: Data not sufficient

Side Effects

-Common side effects of brivaracetam may include dizziness, somnolence, fatigue, headache, and nausea. Serious psychiatric side effects, such as aggression, hostility, irritability, and suicidal thoughts, have been reported in some patients. -Suicidal Behavior and Ideation, somnolence, fatigue, dizziness, and disturbance in coordination, irritability, anxiety, nervousness, aggression, anger, agitation, restlessness, depression, depressed mood, tearfulness, apathy, altered mood, mood swings, affect, psychomotor hyperactivity, abnormal behavior, and adjustment disorder, psychotic disorder along with hallucination, paranoia, acute psychosis, and psychotic behavior, bronchospasm, angioedema

Drug Interactions

-Brivaracetam may interact with other antiepileptic drugs, potentially affecting their plasma concentrations. -Enzyme-inducing antiepileptic drugs may reduce the efficacy of brivaracetam. -Rifampicin, carbamazepine, phenytoin, levetiracetam