Buserelin Acetate

It is a synthetic peptide analog of the natural gonadotropin releasing hormone (GmRH/LHRH) with enhanced biological activity. After repeated administration of buserelin, the secretion of gonadotrophin release and gonadal steroids is significantly inhibited. The pharmacological effect is attributable to the down-regulation of pituitary LHRH receptors.

Indications

-Treatment of prostate cancer -Endometriosis -Uterine fibroids -Precocious puberty -Assisted reproduction (to control ovarian stimulation)

Dosage

-Prostate Cancer: Typically administered as 200 mcg subcutaneously twice a day. -Endometriosis and Uterine Fibroids: Usually 200 mcg subcutaneously twice a day for a period of 3-6 months. -Precocious Puberty: Dosing varies; typically 100-200 mcg subcutaneously twice a day. -Assisted Reproduction: Dosage and frequency are determined by the specific protocol used.

Contra-Indications

-Hypersensitivity to Buserelin Acetate or any component of the formulation -Pregnancy (Category X) -Severe liver or kidney impairment

Special Precautions

-Monitor for signs of hormone withdrawal, especially in cancer patients. -May cause bone density loss; consider monitoring bone health. -Use with caution in patients with cardiovascular conditions. -Regular monitoring of hormone levels is recommended.

Side Effects

-Hot flashes -Headache -Nausea -Fatigue -Mood swings -Injection site reactions -Decreased libido -Vaginal dryness or bleeding (in women) -Osteoporosis with prolonged use

Drug Interactions

-May interact with other hormonal therapies. -Use with caution in combination with medications affecting the liver enzymes (e.g., CYP3A4 inhibitors). -Potential interactions with anticoagulants.