Capreomycin

It is a second line antimycobacterial drug, and is a bacetericidal agent which exhibits activity against human strains of Mycobacterium tuberculosis

Indications

Second line drug for concomitant use with other appropriate anti-tubercular drugs when the first line drugs are ineffective.

Dosage

1 gm daily intramuscularly, followed by 1g i.m. 2-3 times weekly.

Contra-Indications

Hypersensitivity.

Special Precautions

Audiometric, renal function tests and liver function tests must be performed at regular intervals. Paediatrics: Not recommended. Pregnanacy: Safety not established. Lactation: Use with caution.

Side Effects

Tinnitus, vertigo, leucopenia, hypokalemia, urticaria, skin rash, fever, pain and induration at injection site, abnormalities in liver functions.

Drug Interactions

Co-administration of aminoglycoside and other polypeptide antibiotics may increase risk of respiratory paralysis and renal dysfunction. Non depolarising neuromuscular blocking agent enhances neuromuscular blockade due to synergistic effect on myoneural function