Cefixime Trihydrate
It is third generation oral cephalosporin,effective against a wide spectrum of sensitive gram positive, gram negative & anaerobic bacterial pathogens including beta-lactamase producing strains.It has high affinity for penicillin-binding proteins with varying site of activity. It acts by inhibition of bacterial cell-wall synthesis. The elimination half-life is about 3 hours, with little variation over the usual therapeutic dosage range.Infections of respiratory, urinary & biliary tract.
Adult: 200-400mg daily as single or 2 divided doses for 7-14 days. Children: 8mg/kg body-wt. daily as a single or 2 div. doses. Not recommended for children below 6 months
Hypersensitivity.
Hypersensitivity to penicillins. Severe renal impairment. Paediatrics:Safety upto 6 months age not established. Pregnancy: Use with caution. Lactation: Use with caution.
G-I disturbances. Headaches, dizziness. Rashes.
Salicylic acid & Probenecid.
