Cefixime with Dicloxacillin

Cefixime and Dicloxacillin are antibiotics that belong to different classes. Cefixime is a third-generation cephalosporin, while Dicloxacillin is a penicillinase-resistant penicillin. The combination is used to broaden the spectrum of bacterial coverage and combat infections caused by susceptible bacteria.

Indications

This combination is commonly prescribed for the treatment of bacterial infections such as respiratory tract infections, urinary tract infections, skin and soft tissue infections, and other susceptible bacterial infections.

Dosage

Dosage may vary based on the severity of the infection and individual patient factors. It is crucial to follow the prescribed dosage and duration as directed by the healthcare provider.

Contra-Indications

This combination is contraindicated in individuals with a history of hypersensitivity or allergic reactions to cephalosporins, penicillins, or any other component of the formulation. Caution is advised in patients with a history of gastrointestinal disease, particularly colitis.

Special Precautions

-Patients with renal impairment may require dosage adjustments. -Caution in patients with a history of allergic reactions to beta-lactam antibiotics. -Monitoring for superinfections, especially in prolonged therapy.

Side Effects

Common side effects may include gastrointestinal disturbances, allergic reactions (ranging from rash to severe reactions like anaphylaxis), and rare cases of liver dysfunction. Any unusual or severe symptoms should be reported to the healthcare provider promptly.

Drug Interactions

-Concurrent use with probenecid may increase the serum levels of cefixime. -Use with caution when administered with drugs that may cause nephrotoxicity. -Concurrent use with oral anticoagulants may increase the risk of bleeding.