Cefotaxime with Sulbactum

Cefotaxime with Sulbactam is a combination medication that contains two active ingredients: cefotaxime, a third-generation cephalosporin antibiotic, and sulbactam, a beta-lactamase inhibitor. This combination is designed to enhance the antibacterial activity of cefotaxime by preventing the destruction of the antibiotic by beta-lactamase enzymes produced by certain bacteria. Cefotaxime with Sulbactam is available in various pharmaceutical forms, including injections for intravenous or intramuscular administration. The combination is formulated to treat a range of bacterial infections by providing a broad spectrum of antibacterial coverage.

Indications

Cefotaxime with Sulbactam is indicated for the treatment of infections caused by susceptible bacteria. Common indications include respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and gynecological infections.

Dosage

The dosage of Cefotaxime with Sulbactam depends on the specific infection being treated, the severity of the infection, and the patient's overall health. It is administered by a healthcare professional through intravenous or intramuscular routes.

Contra-Indications

Cefotaxime with Sulbactam is contraindicated in individuals with a known allergy to cephalosporin antibiotics or beta-lactamase inhibitors. It should be used with caution in patients with a history of allergic reactions to penicillins.

Special Precautions

Special precautions should be taken in patients with a history of gastrointestinal diseases, particularly colitis. Monitoring for signs of superinfections and allergic reactions is crucial during treatment. It is important to assess renal function regularly, especially in patients with pre-existing renal conditions.

Side Effects

Common side effects may include nausea, vomiting, diarrhea, and allergic reactions. Serious side effects such as severe skin reactions or blood disorders are rare but require immediate medical attention.

Drug Interactions

Cefotaxime with Sulbactam may interact with other medications, including probenecid and aminoglycosides. The healthcare provider should be informed of all medications being taken to prevent potential interactions.