Cefpodoxime with Clavulanate

Cefpodoxime with Clavulanate is a combination of an antibiotic and a beta-lactamase inhibitor. Cefpodoxime, a third-generation cephalosporin, works by inhibiting cell wall synthesis in susceptible bacteria, thereby causing their death. Clavulanate, an inhibitor of beta-lactamase enzymes produced by some bacteria, helps to enhance the efficacy of cefpodoxime by preventing bacterial resistance.

Indications

Cefpodoxime with clavulanate is indicated for treating infections caused by susceptible strains of bacteria. Common indications include: Respiratory tract infections such as pneumonia, bronchitis, and sinusitis Ear infections (otitis media) Skin and soft tissue infections Urinary tract infections Sexually transmitted infections, such as gonorrhea

Dosage

The dosage of cefpodoxime with clavulanate can vary depending on the type and severity of infection, patient age, and other factors. It's essential to follow the dosage instructions provided by a healthcare professional. Typically: For adults, the dosage can range from 200 to 400 mg every 12 hours. For children, the dosage is usually weight-based and administered every 12 hours.

Contra-Indications

Cefpodoxime with clavulanate is contraindicated in: Patients with a known allergy to cefpodoxime, clavulanate, or other beta-lactam antibiotics (e.g., penicillins, other cephalosporins). Patients with a history of severe hypersensitivity reactions to any other ingredients in the medication.

Special Precautions

Renal impairment: Dose adjustments may be necessary in patients with renal impairment. Liver disease: Clavulanate may be processed differently in patients with liver disease, and dose adjustments may be necessary. Pregnancy and breastfeeding: Use during pregnancy and breastfeeding should be approached with caution and only when necessary. A healthcare professional's guidance is essential. History of colitis: Antibiotic use can increase the risk of Clostridioides difficile-associated diarrhea; monitor for symptoms.

Side Effects

Common side effects of cefpodoxime with clavulanate include: Diarrhea Nausea Vomiting Abdominal pain

Drug Interactions

Antacids and H2 blockers: These may decrease the absorption of cefpodoxime. Probenecid: May increase the levels of cefpodoxime in the blood. Oral contraceptives: Antibiotics may reduce the effectiveness of hormonal contraceptives; alternative methods of contraception should be used. Warfarin: Antibiotics may enhance the effects of warfarin, leading to an increased risk of bleeding.