Ceftazidime
It is a broad spectrum, third generation parenteral cephalosporin effective against many Gram negative organisms.Serious infections of the respiratory tract, E.N.T, skin and soft tissue bone, and joints, biliary and G.I. tract. U.T.I. Septicaemia, meningitis. Infections in immunocompromised patients
Adults: 1-6 gm daily in divided doses every 8 or 12 hrs. Children: over 1 yr: 30-100 mg/kg body wt per day in 2-3 divided doses. Max 6 gm daily.
Hypersensitivity to Penicillins or Cephalosporins
neonates and infants, renal or hepatic impairment, prolong use. Paediatrics: Safe. Pregnancy & Lactation:Use with caution. Elderly:decrease dose in case of renal impairment.
G.I. disorders, Pseudomembranous colitis, candidosis, eosinophilia, neutropenia, leucopenia, thrombocytopenia , rise in liver enzymes and blood urea. Pain at injection site.
Aminoglycosides, frusemide used concomitantly leads to nephrotoxicity, Chloramphenicol antagonises ceftazidime.
