Ceftriaxone with Tazobactum

Ceftriaxone with Tazobactam is a combination antibiotic used to treat various infections caused by bacteria. Ceftriaxone is a cephalosporin antibiotic that works by stopping bacterial growth, while Tazobactam is a beta-lactamase inhibitor that helps prevent certain bacteria from breaking down Ceftriaxone.

Indications

-Severe infections including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and intra-abdominal infections. -Infections caused by beta-lactamase-producing strains of bacteria.

Dosage

-Adults: Typically 1-2 grams of Ceftriaxone with 0.5-1 gram of Tazobactam, administered intravenously every 12 hours. The exact dosage may vary depending on the type and severity of the infection. -Pediatrics: Dosage is weight-based and determined by a healthcare provider.

Contra-Indications

-Known allergy to Ceftriaxone, Tazobactam, or any other cephalosporin or beta-lactam antibiotics. -Severe renal impairment without dose adjustment. -Concurrent use of calcium-containing solutions in neonates due to risk of precipitation.

Special Precautions

-Use with caution in patients with a history of gastrointestinal disease, particularly colitis. -Monitor renal and hepatic function regularly. -Avoid use in neonates due to the risk of precipitation with calcium-containing solutions.

Side Effects

-Common: Diarrhea, nausea, vomiting, rash, and injection site reactions. -Serious: Allergic reactions, Clostridium difficile-associated diarrhea, liver enzyme abnormalities, and renal impairment.

Drug Interactions

-May interact with other antibiotics and medications affecting renal function. -Avoid concurrent use with calcium-containing solutions in neonates.