Cefuroxime with Clavulanic Acid

Cefuroxime with Clavulanic Acid is a combination antibiotic used to treat a variety of bacterial infections. Cefuroxime is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis, while Clavulanic Acid is a beta-lactamase inhibitor that prevents the breakdown of cefuroxime by certain bacteria.

Indications

-Respiratory tract infections (e.g., pneumonia, bronchitis) -Urinary tract infections (e.g., cystitis, pyelonephritis) -Skin and soft tissue infections -Sinusitis -Otitis media -Bone and joint infections -Gynecological infections

Dosage

-Adults: Typically, 250-500 mg of Cefuroxime and 125 mg of Clavulanic Acid every 8-12 hours, depending on the severity of the infection. -Children: Dosage is based on weight and type of infection. Generally, 20-40 mg/kg/day divided into 2-3 doses.

Contra-Indications

-Allergy to cephalosporins or penicillins -Severe renal impairment without dose adjustment -History of severe allergic reactions to beta-lactam antibiotics

Special Precautions

-Use with caution in patients with a history of gastrointestinal disease, particularly colitis -Monitor renal function in patients with impaired kidney function -Caution in patients with a history of penicillin allergy due to potential cross-reactivity

Side Effects

-Common: Nausea, diarrhea, abdominal pain, and rash -Rare but serious: Anaphylaxis, severe allergic reactions, liver dysfunction, and Clostridium difficile-associated diarrhea

Drug Interactions

-May enhance the effects of anticoagulants like warfarin -Probenecid may increase Cefuroxime levels by decreasing renal excretion -Concurrent use with certain diuretics may increase the risk of nephrotoxicity