Celecoxib

Celexocib is is a nonsteroidal antiinflammatory drug selective cyclooxygenase (COX-2) inhibitor.

Indications

It indicated for Osteoarthritis (OA) , Rheumatoid Arthritis (RA), Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older, Ankylosing Spondylitis (AS), Acute Pain, Primary Dysmenorrhea (PD)

Dosage

Oral; 50,100,200,400 mg: Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals • OA: 200 mg once daily or 100 mg twice daily • RA: 100 to 200 mg twice daily • JRA: 50 mg twice daily in patients 10-25 kg. 100 mg twice daily in patients more than 25 kg • AS: 200 mg once daily single dose or 100 mg twice daily. If no effect is observed after 6 weeks, a trial of 400 mg (single or divided doses) may be of benefit. • PD: 400 mg initially, followed by 200 mg dose if needed on first day. On subsequent days, 200 mg twice daily as needed.

Contra-Indications

Known hypersensitivity to celecoxib, or any components of the drug product or sulfonamides, History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs, In the setting of CABG surgery

Special Precautions

Hepatic Impairment: Reduce daily dose by 50% in patients with moderate hepatic impairment (Child-Pugh Class B).

Side Effects

Common side effects may include: -Gastrointestinal discomfort -Headache -Dizziness -Edema -Hypertension Serious side effects may include: -Cardiovascular events -Gastrointestinal bleeding -Renal impairment

Drug Interactions

Celecoxib may interact with: -Anticoagulants (e.g., warfarin) Antiplatelet drugs (e.g., aspirin) -ACE inhibitors -Diuretics -Lithium Consultation with a healthcare professional is advised when combining celecoxib with other medications.