300 mg spread over a week. In sulphone resistant cases: 600 mg, weekly preferably after meals. Lepra reactions: 200 mg daily for 3 weeks or as required.
1st trimester of pregnancy.
Renal or hepatic disorders. Paediatrics: Contraindicated in infants. Pregnancy: Contraindicated. Lactation: Not prescribed without indication. Elderly: Use with caution.
Development of red and black pigmentation leading to discolouration of skin, hair and secretions. Dry skin, pruritus, G.I upset, abdominal pain, diarrhoea, reduce or space out dosage.
Ototoxic and nephrotoxic drugs potentiates their toxicity.