Colchicine
Relief of acute gout, short-term prophylaxis of gout.
Relief of acute gout : Adult: Initially, 1mg reduced to 0.5mg every 2-3 hours until pain relief is achieved or GI toxicity occurs. May only he repeated after 3 days from previous treatment. Max. dose: 6mg per course of treatment. Short-term prophylaxis of gout : Adult : 0.5-0.6mg given 1-3 times daily.
Nausea, vomiting and abdominal pain, diarrhoea, GI haemorrhage, rashes, renal and hepatic damage in excessive doses. Rarely peripheral neuritis, myopathy, alopcia and with chronic therapy blood disorders like agranulocytosis, aplastic anaemia.
