Cyclobenzaprine

It is centrally acting muscle relaxant acting on locus ceruleus causing increased release of norepinephrine in ventral horn of spinal cord.

Indications

Short term managemet (ful musculoskeletal conditions.

Dosage

Oral; 5-10 mg twice a day.

Contra-Indications

Hypersensitivity, Heart disease, along with MAO inhibitors

Special Precautions

Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended. Paediatric: Safety below 15 years is not established Pregnancy: Category B; can be used with caution Lactation : Not known if excreted in milk Elderly: More chance of CNS adverse effect, use with caution

Side Effects

Antimuscarinic effects, neurological adverse effects, GI Disorders, Orthostatic hypotension, Tachycardia, hypersensitivity reactions. Rarely, cholestatic jaundice and blood disorders. Endocrine effects, sexual dysfunction, changes in blood sugar. Increased appetite with wt gain, sweating.

Drug Interactions

Alchol, CNS depressant, TCAs, MAO inhibitors.