Daptomycin

It is a cyclic lipopeptide antibacterial agent derived from the fermentation of Streptomyces roseosporus.

Indications

Complicated skin and skin structure infections caused by susceptible isolates of the following Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only). Staphylococcus aureus bloodstream Infections (Bacteremia), Including Those with Right-Sided Infective Endocarditis, Caused by Methicillin-Susceptible

Dosage

4 mg/kg to 6 mg/Kg should be administered intravenously in 0.9% sodium chloride injection once every 24 hours for 7 to 14 days.

Contra-Indications

hypersensitivity to daptomycin

Special Precautions

Paediatric: Safety under 18 year not established Pregnancy: Category B Lactation: administer with caution Elderly: treatment-emergent adverse events were more common in patients ? 65 years of age than in patients

Side Effects

Anaphylaxis/hypersensitivity reactions, Myopathy and rhabdomyolysis, Eosinophilic pneumonia, Peripheral neuropathy, Increased International Normalized Ratio (INR)/prolonged prothrombin time

Drug Interactions

HMG-CoA Reductase Inhibitors