Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase, chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to prior therapy including imatinib, Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) with resistance or intolerance to prior therapy.
Oral; 100-140mg daily. Tablets need to be swallowed, not to crush or chew it.
Hypersensitivity to dasatinib.
Paediatric: Safety not established. Pregnancy: Category D; risk to fetus. Lactation: Secreted in milk, can cause harm to child. Elderly: Toxicity chance increases in elderly over 65 years of age.
Low blood counts, bleeding, pulmonary artery hypertension, diarrhea, headache, cough, skin rash, fever, nausea, tiredness, vomiting, muscle pain, weakness, infections.
Artemether, Omeprazole, Pantoprazole, Phenobarbital, Rabeprazole, Ranitidine, Rifampin, Tacrolimus, Telithromycin, Thiothixene, Toremifene, Trimipramine, Voriconazole, Vorinostat, Ziprasidone.