Deferasirox
It reduces liver iron concentration and serum ferritin levels in patients with transfusional hemosiderosis.Iron chelating therapy : when a patient has chronic iron over load due to blood transfusion (transfusional hemosiderosis).
2 years of age and older : Initial daily dose is 20mg/kg body weight once daily orally on an empty stomach at list 30 minutes before food.Disperse tablets by stirring in water, orange juice apple juice (3.5-7.0 ounces of liquid) until a fine suspension is obtained and swallow the suspension.
Hypersensitivity to deferasirox or its component; creatinin clearance less than 40mL/minute or serum creatinine more than 2-times than normal values; high risk myelodysplastic syndrome; advanced malignancies; platelet counts less than 50x109/L.
Before starting therapy, obtain base line serum ferrintin and iron levels, do not chew or swallow the tablet; stop the drug if there is a serious side effect - allergic reaction/anaphylaxis, Kidney Problems, liver problems, stomach bleeding, Problems with vision or hearing, fever chills, body aches, flu sympotms, sore mouth and throat, easy bruising, unsual bleeding (nose, mouth, vagina, or rectum), purple red pinpoint spots under skin; severe blistering, peeling, and red skin rash. Do not take
Nausea, vomiting, diarrhea, stomach pain, dizziness, anxiety, tiredness, insomnia, mild rash, discolored skin, headache, cough, sinus pain, runny or stuffy nose.
Alendronate, ibandronate, pamidronate, etidronate, risedronate, zoledronic acid. Macrolides antibiotics, anticoagulants, cholesterol, lowering drugs, heart and blood pressure medication, heart rhythm medications, birth control pills, HIV medicines, medicines, used to prevent organ transplant rejection, NSAIDs, sedatives, steroids.
