DESAMINO-OXYTOCIN

Desamino-oxytocin is a synthetic analog of oxytocin, a hormone naturally produced by the hypothalamus and released by the pituitary gland. It is used in medical settings primarily for its uterotonic properties, which help stimulate contractions of the uterus.

Indications

-Induction or augmentation of labor -Management of postpartum hemorrhage -Control of uterine bleeding

Dosage

The dosage of Desamino-oxytocin should be individualized based on the patient's condition and response to the treatment. It is typically administered intravenously or intramuscularly in a hospital setting under the supervision of a healthcare professional.

Contra-Indications

-Hypersensitivity to oxytocin or any of its analogs -Conditions where vaginal delivery is contraindicated, such as certain cases of fetal distress, severe preeclampsia, or eclampsia -Patients with significant cephalopelvic disproportion

Special Precautions

-Use with caution in patients with cardiovascular disorders -Monitor fluid balance to avoid water intoxication -Continuous monitoring of uterine activity and fetal heart rate is recommended during administration

Side Effects

-Nausea and vomiting -Uterine hyperstimulation -Hypotension -Water intoxication -Allergic reactions

Drug Interactions

-Prostaglandins may potentiate the effect of Desamino-oxytocin, increasing the risk of uterine hyperstimulation. -Concurrent use with other oxytocic agents should be avoided.