Dextran

Dextran is a complex carbohydrate polymer composed of glucose molecules linked together. It is commonly used in the medical field for its ability to increase blood volume and prevent clot formation. Dextran is a high molecular weight polysaccharide derived from the fermentation of sucrose by certain bacteria. It is available in various forms, with Dextran 40 and Dextran 70 being the most commonly used. The substance is known for its ability to increase plasma volume, making it useful in medical settings to treat conditions related to blood volume deficiency.

Indications

Dextran is primarily indicated for the following medical conditions: -Hypovolemia (low blood volume) -Shock (due to trauma, surgery, or other causes) -Blood clot prevention during surgical procedures -Peripheral vascular disorders -Thrombosis prevention

Dosage

The dosage of Dextran varies depending on the specific medical condition being treated and the patient's individual needs. It is typically administered intravenously under the supervision of a healthcare professional.

Contra-Indications

Dextran is contraindicated in individuals with the following conditions: -Hypersensitivity or allergy to Dextran or its components -Severe dehydration -Congestive heart failure -Severe renal impairment -Hemorrhagic disorders

Special Precautions

Caution should be exercised in patients with a history of heart disease, renal dysfunction, or coagulation disorders. Monitoring of blood pressure, electrolytes, and coagulation parameters may be necessary during Dextran therapy.

Side Effects

Common side effects of Dextran may include: -Fever -Chills -Nausea -Vomiting -Allergic reactions -Hypotension

Drug Interactions

Dextran may interact with certain medications, such as anticoagulants, antiplatelet drugs, and fibrinolytics. Close monitoring and adjustment of dosage may be necessary when Dextran is used in combination with these medications.