Diloxanide Furoate

It is highly effective luminal amoebicide: directly kill trophozoites responsible for production of cysts. No systemic antiamoebic activity is evident despite its absorption. Diloxanide furoate exerts no antibacterial action. It is less effective in invasive amoebic dysentery, probably because of a poor tissue amoebicidal action. It has produced high cure rates in mild intestinal amoebiasis and in a symptomatic cystpassers.

Indications

-Treatment of asymptomatic cyst carriers of Entamoeba histolytica -Treatment of acute and chronic intestinal amoebiasis -Often used in combination with other antiprotozoal drugs to treat amoebic infections

Dosage

-Adults: 500 mg three times daily for 10 days. -Children 20 mg/kg body wt daily in divided doses. All for 5-10 days. -Always follow the healthcare provider’s instructions and complete the full course of treatment.

Contra-Indications

-Not to be used in systemic amoebiasis. -Hypersensitivity to Diloxanide Furoate or any component of the formulation -Not recommended for use in pregnant or breastfeeding women unless specifically prescribed by a healthcare provider

Special Precautions

-Use with caution in patients with hepatic impairment -Not intended for the treatment of extraintestinal amoebiasis -Ensure hydration during the treatment period -Pregnancy & Lactation: Use with caution.

Side Effects

-Gastrointestinal disturbances such as nausea, vomiting, and abdominal cramps. -Flatulence -Allergic reactions like skin rash and itching in sensitive individuals -Early urticaria.

Drug Interactions

-May interact with other antiprotozoal or antibiotic medications -Inform your healthcare provider about any other medications or supplements being taken