Diphenylmethanes (Bisacodyl)

(Phenolphthalein, Bisacodyl):- They are partly absorbed and re-excreted in bile: entero-hepatic circulation is more important in phenolphthalein, which can produce protracted action.

Indications

All forms of constipation, e.g. in bedridden patients, due to change of food or environment, illness or digestive disorders. Relief of evacuation in painful conditions such as haemorrhoids. Pre-and postoperatively. Preparation for barium enema; preparation of colon for proctosigmoidoscopy.

Dosage

Bisacodyl : 5-15 mg at bedtime.Phenol-phthalein: 60-130 mg at bedtime.

Contra-Indications

Acute surgical abdomen.

Special Precautions

First 3 months of pregnancy. The concurrent administration of antacids (Sod. bicarbonate) and milk should be avoided.

Side Effects

Abdominal discomfort. Soreness in the anal region due to leakage of the suppository base.