DIPYRIDAMOLE
It improves the blood & oxygen supply to the myocardial cells by inducing maximum dilation of the coronary vessels. The development of collateral vessels is also enhanced. It acts by preventing uptake & degradation of adenosine which is a local mediator involved in auto regulation of coronary flow in response to ischaemia. It dilates resistance vessels & abolishes autoregulation, but has no effect on larger conducting coronary vessels.Coronary insufficiency. Prophylaxis of coronary & cerebral thrombosis in post M.I. and post-stroke patients, as well as to prevent thrombosis in patients with prosthetic heart valves platelet disoders.
Adults: 150-225 mg per day in divided doses on empty stomach at least 2 hrs. before food. Children: 5-10 mg/kg bodywt.
None known.
Patients with rapidly worsening angina. Subvalvular aortic stenosis or haemodynamic instability. (Myocardial infarction). Pregnancy. Lactation, ‘Steal phenomena’.
Rash, nausea, worsening of angina and cardiac arrhythmias, dizziness, headache, diarrhoea, flushing.
Potentiates effects of oral anticoagulants and anti-arrhythmic agent adenosine
