Divalproex

Indications

Petitmal, alternative/adjuvant drug for grandmal, psychomotor and myoclonic & temporal lobe epilepsies, Migraine & Mania.

Dosage

Epilepsy : Adults : Initially, 15mg/kg/day, increase the dose by 5 to 10mg/kg/week as tolerated. Maximal recommended dosage is 60mg/kg/day. Migraine : 250mg twice daily (starting dose). Mania disorder in Bipolar Disorder : Initial dose is 750mg daily in divided doses.

Contra-Indications

Liver impairment, Concurrent administration of Clonazepam, Hypersensitivity.

Special Precautions

Majory surgery, Mental retarded children with epilepsy, Pregnancy & women of child bearing potential.

Side Effects

Anorexia, vomiting, drowsiness, ataxia, tremor, loss of hair, increased blood ammonia, rashes, weight gain, oedema, fulminant hepatitis.

Drug Interactions

Blood level increased by aspirin and reduced by carbamazepine, phenobarbitone, phenytoin and primidone.