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It is an antineoplastic agent.


Cancer : Breast, non-small cell lung, prostate, bladder, stomach, esophagus, overy, head and neck.


Administered parenterally. The dose should be individualized depending on the size of the patient and whether or not other medicines are also being taken. Adult:60 to 100mg/1.73m2 intravenously.


Hypersensitivity , alcohol abuse or history of, chickenpox, herps zoster, fluid in lungs, infection, liver disease.

Special Precautions

Immunization specifically persons living in the patient's household should not take oral polio vaccine. Paediatric : Only limited studies are done. Pregnancy: Contraindicated. Lactation : Generally not recommended. Elderly : Use with caution.

Side Effects

Mild nausea and vomiting, headache, allergic reaction, infection, leukopenia, thrombocytopenia, breathing problem, cough, hoarsness, wheezing, dizziness, tiredness, weakness, dysphagia, palpitation, tightness in chest, chest pain, heart problem, hypotension, or hypertension, congestion, diarrhoea, arthalgia, myalgia, puffiness of face, stomatitis, edema, weight gain, tingling and numbness of extremities, black-tarry stools, hematuria, difficult and painful alopecia, induration at the site of inj

Drug Interactions

Amhotericin-B, Ketoconazole, antithyroid agents, azathioprine, chloramphenicol, plicamycin, erythromycins, troleandomycin, colchicine, flucytosine, ganciclovir, zidovudine, interferon, cyclophosphamide, orphenadine, testosterone, midazolam, radiation therapy.

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