Doripenem
It is an ultra-broad spectrum injectable antibiotic. It is a beta-lactam and belongs to the subgroup of carbapenems.Doripenem is indicated for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, including pyelonephritis, and hospital-acquired pneumonia, including ventilator-associated pneumonia.
-Adults: The usual dose is 500 mg every 8 hours administered as a 1-hour intravenous -infusion. The treatment duration depends on the infection type and severity. -Renal Impairment: Dosage adjustments are required for patients with moderate to severe renal impairment.
-Known hypersensitivity to doripenem or other carbapenem antibiotics. -Severe allergic reactions to beta-lactam antibiotics.
-Monitor renal function during treatment, especially in patients with pre-existing renal conditions. -Use with caution in patients with a history of seizures or central nervous system disorders. -Be alert for signs of anaphylaxis during administration.
-Common: Nausea, diarrhea, headache, rash. -Serious: Seizures, severe allergic reactions, Clostridium difficile-associated diarrhea.
-Probenecid: May increase blood levels of doripenem. -Valproic Acid: Concomitant use may reduce valproic acid levels, increasing the risk of seizures.
