DOTHIEPIN HCL

Indications

Depression, depression associated with anxiety.

Dosage

Adults: Initially 75 mg daily in divided doses or single dose at night increasing to 150 mg daily. Elderly: 50-75 mg daily initially. Increase dose with caution and close supervision. Not recommended for children. Maint : 150 mg as a single dose at night.

Contra-Indications

Contra-Indications are same as that for Imipramine.

Special Precautions

Special Precautions are same as that for Imipramine.

Side Effects

Ventricular fibrillation and renal failure, drowsiness, blurred vision, sweatig, palpitation, tremors and skin rash, bone marrow depression and agranulocytosis.

Drug Interactions

MAOIs potentiate action hence should not be given concurrently or within 14 days of stopping MAOIs. Cigarette smoking enhances the metabolism. Reduces the effectiveness of antihypertensive drugs. Barbiturates reduces antidepressant effect of dothiepin.Diuretics may lead to hypotension.