Postanesthetic use, Drug-induced CNS Depression.
Postanesthetic use : I.V.infusion at 0.5-1.5mg/kg. Max 4mg per kg. Drug-induced CNS Depression : Priming dose 2mg/kg I.V. Repeat in 5 minutes and then every 1-2 hours until the patient awakens.Total maximum daily dose 3 grams.
Severe heart disease and hypertension, severe COPD, epilepsy, cerebral oedema, hyperthyroidism, ischemic heart disease, status asthmaticus, epilepsy, convulsive disorders, phaeochromcytoma, recent cerebrovascular accident, children under 12.
Seen only in overdosage. Hypertension, tachycardia and fasciculations; agitation, confusion and dyspnoea.