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Doxylamine with Pyridoxine HCl is a combination medication commonly used to alleviate nausea and vomiting during pregnancy. Doxylamine is an antihistamine with antiemetic properties, and Pyridoxine HCl is a form of vitamin B6.


-Nausea and Vomiting in Pregnancy (NVP): Specifically indicated for the relief of symptoms associated with morning sickness during pregnancy.


-Dosage may vary, but a typical regimen involves taking one tablet at bedtime and another in the morning. The medication is usually taken orally. -2 tab at bed time. If required one additional tab in the morning and one tablet in the afternoon.


-Hypersensitivity: Avoid in patients with known hypersensitivity to doxylamine, pyridoxine, or related components. -Monoamine Oxidase Inhibitors (MAOIs): Contraindicated in individuals taking MAOIs.

Special Precautions

-Narrow angle glaucoma, urinary retention, pyloro-duodenal obstruction, epilepsy, severe cardio-vascular disorders. -Seizure Disorders: Use with caution in patients with a history of seizure disorders. Closed-Angle Glaucoma: Caution is advised in patients with closed-angle glaucoma.

Side Effects

-Common side effects may include drowsiness, dry mouth, and blurred vision. Serious side effects are rare but may include allergic reactions or severe drowsiness. -Drowsiness, dizziness, vertigo or disorientation, nervousness, dry mouth, irritability, GI disturbances.

Drug Interactions

-Central Nervous System (CNS) Depressants: Enhanced sedative effects when used concomitantly with other CNS depressants. -MAOIs: Potential for hypertensive crisis if taken with MAOIs. -CNS depressants, MAOIs, anti-muscarinic agents.

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