DROPERIDOL

Droperidol is an antipsychotic and antiemetic medication used primarily to prevent nausea and vomiting, particularly postoperatively and during diagnostic or surgical procedures. It works by blocking dopamine receptors in the brain.

Indications

-Prevention of postoperative nausea and vomiting -Management of severe nausea and vomiting in various medical conditions -Adjunct to anesthesia for calming effects

Dosage

-Adults: The typical dose for preventing postoperative nausea and vomiting is 0.625 to 1.25 mg given intravenously or intramuscularly before or during anesthesia. -Children: The dosage must be determined by a healthcare provider based on body weight and clinical condition.

Contra-Indications

-Hypersensitivity to Droperidol or any component of the formulation -Patients with known or suspected QT prolongation -Severe CNS depression -Pheochromocytoma -Parkinson's disease

Special Precautions

-Use with caution in patients with cardiac disease due to potential for QT prolongation -Monitor ECG for patients at risk of QT prolongation -Avoid in patients with severe hepatic impairment -Caution in patients with respiratory depression or obstruction -Use with caution in the elderly, and adjust doses accordingly

Side Effects

-Drowsiness -Hypotension -Tachycardia or bradycardia -QT prolongation and potential for torsades de pointes -Extrapyramidal symptoms (e.g., dystonia, akathisia) -Restlessness -Anxiety

Drug Interactions

Avoid concurrent use with drugs that may prolong QT interval e.g. certain antihistamines, antimalarials, calcium-channel blockers and antidepressants. May potentiate the action of other CNS depressants e.g. barbiturates, alcohol. Caution when using with drugs that may induce hypokalaemia or hypomagnesemia.