DROPERIDOL

it is an antidopaminergic drug used as an antiemetic .

Indications

Post-op nausea and vomiting.

Dosage

dose should beindividualised, IV/IM Max initial dose: 2.5 mg; additional doses of 1.25 mg may be given if needed.

Contra-Indications

QT prolongation, hypersensitivity

Special Precautions

prolonged QT syndrome, clinically significant bradycardia (less than 50 bpm), any clinically significant cardiac disease, treatment with Class I and Class III antiarrhythmics, treatment with monoamine oxi-dase inhibitors (MAOI's), concomitant treatment with other drug products known to prolong the QT interval, electrolyte imbalance, in particular hypokalemia and hypo-magnesemia, or concomitant treatment with drugs (e.g., diuretics) that may cause electroHepatic or renal impairment. Paediat

Side Effects

Dry mouth, constipation, micturition difficulty, blurred vision, mydriasis, delirium, agitation, catatonic-like states, insomnia, nightmares, depression, miosis, convulsions, nasal congestion. CV effects; hypersensitivity reactions, haematological disorders, extrapyramidal dysfunction. Amenorrhoea, galactorrhoea, gynaecomastia, weight gain and hyperglycaemia, and altered glucose tolerance. Pain and irritation at the Inj site. Post-op drowsiness.

Drug Interactions

Avoid concurrent use with drugs that may prolong QT interval e.g. certain antihistamines, antimalarials, calcium-channel blockers and antidepressants. May potentiate the action of other CNS depressants e.g. barbiturates, alcohol. Caution when using with drugs that may induce hypokalaemia or hypomagnesemia.