Dutasteride with Tamsulosin
Dutasteride with Tamsulosin is a combination medication used in the management of benign prostatic hyperplasia (BPH) in adult males. It contains two active ingredients: dutasteride, a 5-alpha-reductase inhibitor, and tamsulosin, an alpha-blocker. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT), reducing prostate size, while tamsulosin relaxes the muscles in the prostate and bladder neck, improving urinary flow.Dutasteride with Tamsulosin is indicated for the treatment of signs and symptoms of BPH in men with an enlarged prostate.
The recommended dosage is usually one capsule (0.5 mg dutasteride/0.4 mg tamsulosin) taken orally once daily with a meal. It is important to swallow the capsule whole and not crush or chew it.
This medication is contraindicated in patients with known hypersensitivity to dutasteride, tamsulosin, or any other components of the formulation. It is also contraindicated in women and children.
-Caution is advised in patients with a history of orthostatic hypotension. -Patients with severe liver impairment should be monitored closely. -The combination may increase the risk of a rare side effect known as priapism, and patients should seek medical attention if they experience prolonged or painful erections.
Common side effects may include dizziness, lightheadedness, retrograde ejaculation, and sexual dysfunction. Serious side effects such as allergic reactions, severe hypotension, or liver problems should be reported to a healthcare professional promptly.
-Concomitant use with other alpha-blockers may increase the risk of hypotension. -Medications affecting CYP3A4 enzymes may alter the metabolism of tamsulosin.
